Pitt Innovators were issued 10 patents in August 2022.
Featured patent: 11,406,736 “Vascular Extracellular Matrix Hydrogel”
Extracellular matrix (ECM) bioscaffolds are tissue-specific biomaterials with inherent bioactivity and native structural features that enable their use as three-dimensional in vitro cell culture substrates for biologic discovery of cellular mechanisms or as disease models. Certain decellularized tissues also show promise for therapeutic tissue regeneration in a variety of applications as they retain proteins that enhance cellular adhesion and invoke signaling to influence cellular differentiation and regenerative potential. Pitt innovators led by Julie Phillippi, associate professor of cardiothoracic surgery and bioengineering, have developed ECM compositions useful as in vitro cell culture substrates or in vivo biomaterials for tissue repair in cardiovascular applications. This invention embodies a method wherein decellularized ECMs from blood vessels (e.g. porcine or human aorta adventitia in one aspect) that are formulated into hydrogels that can be used as substrates for in vitro cell culture and in vivo tissue regeneration.
For more information on this technology, including licensing inquiries, contact Alex Ducruet at aducruet@innovation.pitt.edu.
Below is a listing of all patents issued to Pitt innovators in August 2022.
| Title | Inventor(s) | Licensing Manager | Status | ||||
| Vascular Extracellular Matrix Hydrogel | Julie Phillippi; Thomas Gleason; George Fercana; Stephen Badylak | Alex Ducruet | Available for Licensing | ||||
| Activators of CXCR3 for the Treatment of Angiopathies of the Eye | Alan Wells; Cecelia Yates-Binder; Joel Schuman | Janice Panza | Licensed | ||||
| Methods for Preparation of a Terminally Sterilized Hydrogel Derived From Extracellular Matrix | Timothy Keane Jr.; Stephen Badylak; Christopher Dearth; Neill Turner | Alex Ducruet | Licensed | ||||
| Artificial Cell Constructs for Cellular Manipulation | Steven Little | Janice Panza | Optioned | ||||
| Compositions and Methods for Treatment of Inflammatory Disorders | David Hackam; Peter Wipf; Chhinder Sodhi | Maria Vanegas | Available for Licensing | ||||
| Spak Kinase Inhibitors as Neuroprotective Agents | Mohammad Bhuiyan; Dandan Sun; Xianming Deng; Jinwei Zhang; Brandley Molyneaux | Maria Vanegas | Available for Licensing | ||||
| Analysis of Eye and Pupil Movement Coordination in Vergence Testing for Detection of Acute MTBI | Carey David Balaban; Alexander Kiderman; Michael Hoffer; Mikhaylo Szczupak | Robert Racunas | Available for Licensing | ||||
| Identification of Mutations in Herpes Simplex Virus Envelope Glycoproteins That Enable or Enhance Vector Retargeting to Novel Non-HSV Receptors | Justus Cohen; Joseph Glorioso; Hioaki Uchida | Maria Vanegas | Licensed | ||||
| DNA Nanostructure Patterned Templates | Haitao Liu; Hyo Kim; Cheng Tian | George Coulston | Not Available | ||||
| Expression of NKG2D Activating Ligand Proteins for Sensitizing Cancer Cells to Attack by Cytotoxic Immune Cells | Paola Grandi; Ndukaku Amankulor; Joseph Glorioso | Maria Vanegas | Licensed | ||||