Pitt innovators were issued 11 U.S. patents in January 2022.
Featured patent: 11,214,560 “Modulators of p97 AAA Atpase Activity”
Inhibition of p97 ATPase, a molecular cleanup mechanism, triggers downstream cellular effects, including the suppression of cellular proliferation that makes cancer such a dangerous disease. Pitt innovators led by Donna Huryn, Professor of Pharmaceutical Science, and Peter Wipf, Distinguished University Professor, Department of Chemistry, along with colleagues at Duke University and the University of Pennsylvania, have discovered p97 inhibitors that may lead to new treatments for cancer and possibly also neurodegeneration and genetic disorders involving p97 mutations.
For more information on this technology, including licensing, contact Maria Vanegas at mvanegas@innovation.pitt.edu.
Below is a listing of all patents issued to Pitt innovators in January 2022.
| Patent Number |
Title | Inventor(s) | Licensing Manager | Status | |||
| 11,214,779 | Activatable CRISPR/Cas9 for Spatial and Temporal Control of Genome Editing | James Hemphill; Erin Borchardt; Aravind Asokan; Alexander Deiters | Andrew Remes | Available for licensing | |||
| 11,213,258 | Variable Index for Determining Patient Status | Ata Kaynar; Michael Schnetz | Janice Panza | Available for licensing | |||
| 11,213,545 | ECM Hydrogel for Treating Esophageal Inflammation | Lindsey Saldin; Stephen Badylak; Juan Gutierrez | Alex Ducruet | Licensed | |||
| 11,214,560 | Modulators of P97 AAA Atpase Activity | Donna Huryn; Peter Wipf; Matthew LaPorte | Maria Vanegas | Available for licensing | |||
| 11,213,482 | SARS-COV-2 Subunit Vaccine and Microneedle Array Delivery System | Andrea Gambotto; Eun Kim; Louis Falo | Maria Vanegas | Available for licensing | |||
| 11,219,659 | Anti-Psychotic Composition and Treatment Methods | Kadiamada Chengappa; Dean Salisbury | Andrew Remes | Available for licensing | |||
| 11,220,703 | Fluorometric and Colorimetric Quantification Techniques with Autonomously and Reversibly Stalling Catalytic Signal Amplification | Kazunori Koide; Matthew Tracey; Christopher Welch; Xiaodong Bu; Junyong Jo | George Coulston | Available for licensing | |||
| 11,219,640 | Inorganic Nitrite to Improve Cardiopulmonary Hemodynamics | Edwin Parsley; Mark Gladwin; Hunter Champion | Maria Vanegas | Licensed | |||
| 11,224,685 | Self-Regulating Device for Modulating Inflammation | Yoram Vodovotz; Alexey Solovyev; David Okonkwo; Maxim Vyacheslavovich; Qi Mi; Jorg Gerlach; Gregory Constantine | Maria Vanegas | Available for licensing | |||
| 11,229,676 | Methods and Compositions for Diagnosis and Prognosis of Renal Injury and Renal Failure | John Kellum Jr.; Paul McPherson | Alex Ducruet | Available for licensing | |||
| 11,230,775 | Non-Noble Metal Based Electro-Catalyst Compositions for Proton Exchange Membrane Based Water Electrolysis and Methods of Making | Prashant Kumta; Karan Kadakia; Moni Datta; Oleg Velikokhatnyi; Prashanth Hanumantha | Janice Panza | Available for licensing | |||